منابع مشابه
Bisphosphonate-Related Osteonecrosis of the Jaw Mimicking Bone Metastasis
Osteonecrosis of the jaw is usually a potential complication of bisphosphonate therapy. In a cancer patient, this disease entity can be misdiagnosed as a metastatic lesion. Our aim is to make clinicians aware of bisphosphonate associated osteonecrosis of the jaw to prevent misdiagnosis and initiate proper treatment at the earliest. We present the case of a breast cancer patient with multiple bo...
متن کاملEffect of Bisphosphonate on Osteoclast of Bone
Bisphosphonates are synthetic analogues of naturally occurring pyrophosphate molecule and are potent inhibitors of osteoclastic bone resorption. Bisphosphonates bind to hydroxyapatite crystals with high affinity and after incorporation by osteoclasts, the primary target cell, it inhibits osteoclastic bone resorption. The anti-resorptive effect has been shown to occur in organ culture as well as...
متن کاملRECENT ADVANCES Bisphosphonate treatment of bone disease
MECHANISM OF ACTION AND RELATIVE POTENCY Bisphosphonates are chemical analogues of pyrophosphate. The presence of a carbon rather than oxygen atom at the centre of the molecule prevents its breakdown. The two phosphonate groups are attached directly to the carbon atom from which also extend the R1 and R2 side chains (fig 1). The R1 side chain is usually a hydroxyl group and is often referred to...
متن کاملBone metastasis and rehabilitation.
Patients with cancer that has metastasized to bone will frequently develop functional problems that may respond to rehabilitative treatment. Many rehabilitation professionals, however, are concerned about the possibility of producing pathologic fracture with their treatment. Several methods have been proposed for identifying which malignant lesions in bone are at risk of fracture. In this artic...
متن کاملTreatment efficacy of 153Sm-EDTMP for painful bone metastasis
Introduction: Involvement of the skeleton can cause an excruciating pain in two-thirds of terminal patients with a history of malignancy. Due to several limitations of other therapies, such as analgesics, bisphosphonates, chemotherapy, hormonal therapy and external beam radiotherapy; bone-seeking radiopharmaceuticals have an important role in palliation of pain from bone metastases. Although th...
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ژورنال
عنوان ژورنال: RADIOISOTOPES
سال: 1998
ISSN: 1884-4111,0033-8303
DOI: 10.3769/radioisotopes.47.667